Over the 90-minute session, participants consumed an average (3.29 ± 0.7) beers when treated with placebo and (2.28 ± 0.6) beers when treated with puerarin. Participants delayed opening beers by an average of 10 additional minutes (23%) and took 4 min longer to consume beers (18%). 7 depicts the effects of puerarin on the amount of beer consumed (Penetar et al, 2012). We conclude that puerarin is an active isoflavone that has effects that parallel kudzu extract (Lukas et al, 2005). However, the combination of the other two major isoflavones (daidzin and daidzein) in the Alkontrol-herbal preparation enhances the total efficacy in reducing alcohol drinking, and therefore is a superior strategy than focusing in a single entity.
Any product carrying a THR mark can be relied upon to contain the amounts of herb/active ingredient as stated on the bottle. Kudzu, whose scientific name is Pueraria mirfica, is a vine used in Chinese medicine for a variety of health promoting purposes. Ultimately, a comprehensive approach to health and well-being, including evidence-based https://ecosoberhouse.com/ treatments, remains paramount. Kudzu root is a rich source of antioxidants, which can help protect the body against damage from free radicals. Free radicals are molecules that can damage cells, leading to a range of health issues. The kudzu plant is a vine that resembles poison ivy and is native to several Asian countries.
Fortifier, Tonic, and Rejuvenating Plants and the Adaptogen Concept
Isoflavones, the major components of kudzu, are thought to be responsible for its potential effects. Ibogaine, a natural alkaloid, isolated from the root bark of Tabernanthe iboga, has been reported to markedly reduce voluntary alcohol https://ecosoberhouse.com/article/kudzu-extract-and-alcohol-addiction-can-it-help-you-drink-less/ intake in alcohol-preferring rats in 2-bottle choice and operant self-administration paradigms [132]. The possible mechanism was mediated by the glial cell line-derived neurotrophic factor (GDNF) in the ventral tegmental area [133].
The extract of Fructus evodiae could be used as a potential remedy for hangover symptoms induced by alcohol on mice by stimulating the expression of hepatic alcohol metabolizing and antioxidant enzymes [51]. The results showed that among all groups the plasma alcohol concentrations were the lowest in Fructus evodiae treated groups. Moreover, the expressions of liver alcohol metabolizing and antioxidant enzymes were also enhanced. The relative expression of ADH and Zn-Cu SOD increased more in treatment groups than that in positive controls. In another study, a water extract of Fructus evodiae possessed the ability to alleviate alcohol-induced gastric lesions in rats by strengthening the mucosal barrier integrity and increasing gastric mucosal nitric oxide synthesis [52].
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During the present study we have gathered evidence that kudzu extract may alter blood ethanol levels and that this change in pharmacokinetics may result in an increased rate of entry into the central nervous system. Such an effect might increase the rewarding effects of the first drink consumed, especially when higher doses are consumed, and the desire for subsequent drinks might be delayed. Thus, the net effect of kudzu extract would not be to eliminate drinking completely, but to reduce binge drinking to a more manageable number of drinks from which complete withdrawal (via complementary methods) might be possible. Meanwhile, the roots of Pueraria lobata showed inhibitory activity against mitochondrial ALDH2, and could increase the concentration of acetaldehyde in blood.
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